Effects of parabens on apoptosis induced by serum-free medium |
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| Authors: | Mari Egawa Kentaro Aoki Yongkun Sun Toshiyuki Hosokawa Takeshi Saito Masaaki Kurasaki |
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| Institution: | 1. Graduate School of Environmental Science, Hokkaido University , Sapporo , Japan;2. Institute for the Advancement of Higher Education, Hokkaido University , Sapporo , Japan;3. Faculty of Health Sciences, Hokkaido University , Sapporo , Japan;4. Graduate School of Environmental Science, Hokkaido University , Sapporo , Japan;5. Faculty of Environmental Earth Science, Hokkaido University , Sapporo , Japan |
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| Abstract: | Alkyl esters of p-hydroxybenzoic acids (parabens), an endocrine disrupter, are used as preservatives in cosmetics and foods. In this study, to understand the relationship between parabens and differentiation in infants, the effects of parabens on apoptosis induced by serum deprivation in PC12 cells were investigated. In addition, apoptosis-related factors were assayed. As results, a tendency toward enhancement of apoptosis was observed in the cells cultured in the serum-free medium with methylparaben, and this tendency was suggested to be related to the contents of BAD, a pro-apoptotic protein. Butylparaben did not show any tendency to enhance apoptosis. |
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| Keywords: | PC12 cell endocrine disrupter food additives apoptotic factors methylparaben butylparaben |
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