首页 | 本学科首页   官方微博 | 高级检索  
     检索      


Lung subcellular fractions and surfactant lipid metabolism of rats exposed with DDT or endosulfan intratracheally
Authors:Satya Narayan  H M Dani  U K Misra
Institution:1. Department of Biochemistry, V. P. Chest Institute , University of Delhi , India;2. Department of Surgery , The University of Texas, Medical Branch , 6.202 Old John Sealy, E32, Galveston, Texas, 77550;3. Department of Biochemistry , Panjab University , Chandigarh, India;4. Department of Biochemistry, V. P. Chest Institute , University of Delhi , India
Abstract:Abstract

The effect of intracheally administered DDT (5 mg/100 g body weight) or endosulfan (1 mg/100 g body weight) for three cosecutive days have been studied on lipid metabolism of rat lung subcellular fractions. Both the insecticides did not affect the lung weight and the protein contents of microsomes, lamellar bodies and surfactant but significantly increased the phospholipid contents of microsomal and surfactant system. Most of the neutral lipid components of lung subcellular fractions were also increased by DDT or endosulfan treatments, except that of surfactant triglycerides which were decreased by DDT treatment. DDT or endosulfan both increased the incorporation of radioactive methyl‐3H]choline into microsomal phosphatidylcholine (PC) and surfactant dipalmitoylphosphatidylcholine (DPPC) without affecting the incorporation of radioactive methyl‐14C]methionine, showing the increased synthesis of PC via CDPcholine pathway. The results presented in this communication showed that DDT and endosulfan, the two different chloroinsecticides have similar effects on microsomal lipid metabolism but produce different biochemical manifestations on the secretion of surfactant phospholipids.
Keywords:Intratracheal administration  DDT  Endosulfan  Lung  Microsomes  Lamellar bodies  Surfactant  Lipid metabolism
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号