Threshold estimation from the linear dose-response model: Method and radiation data |
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| Authors: | David J Schaeffer Konanur G Janardan Harold W Kerster |
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| Institution: | (1) Division of Water Pollution, Illinois Environmental Protection Agency, 2200 Churchill Road, 62706 Springfield, Illinois;(2) Sangamon State University, 62708 Springfield, Illinois;(3) California State University, 95819 Sacramento, California |
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| Abstract: | The linear dose-response model is considered a conservative, nonthreshold relationship. This is based on a confusion between the sufficient condition (that is, zero slope at zero dose) and the necessary condition (that is, response distinguishable from zero). Once the threshold is properly defined, it is shown that the linear model predicts thresholds for radiation data in good agreement with experimental results. |
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| Keywords: | Linear dose-response model Risk assessment Carcinogens |
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