农药致慢性细胞毒性及基因毒性机制研究进展

大量流行病学研究和体内、体外检测分析表明,长期低剂量接触农药可以导致人体细胞和分子损伤,诱导细胞凋亡。农药致细胞及DNA损伤的机制主要与DNA加合物的形成、DNA单链和/或双链的断裂有关。此外,氧化应激参与农药致细胞及DNA损伤的过程,可能成为农药致细胞及DNA损伤的促发因素。从总体上看,其具体分子机制还不十分清楚,有待进一步研究。

Progress in Mechanism of Pesticide-induced Cytotoxicity and Genotoxicity

The cytotoxicity and genotoxicity in human cells induced by chronic exposure of pesticides have been confirmed, proved by the epidemiologic studies and many alternative test methods in vivo and in vitro. The formation of DNA adduct and DNA single and/or double strand breakage are the main forms of DNA damage. In addition, oxidative stress plays an important role and may be a promoting factor in the mechanism of pesticide-induced cytotoxicity and genotoxicity in human cells. Overall, the specific molecular mechanism of pesticide is not entirely clear at present and further researches are needed to be done.