Decrease of PCDD/F levels in human blood from Germany over the past ten years (1989-1998) |
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Authors: | Wittsiepe J Schrey P Ewers U Selenka F Wilhelm M |
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Institution: | Ruhr-Universit?t Bochum, Abteilung für Hygiene, Sozial- und Umweltmedizin, Germany. wittsiepe@hygiene.ruhr-uni-bochum.de |
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Abstract: | 744 whole blood samples of normal subjects from Germany collected in 1989-1998 have been analyzed for polychlorinated dibenzo-p-dioxins (PCDD) and dibenzofurans (PCDF) by capillary gas chromatography/high resolution mass spectrometry. Over the examined time period a continuous decrease of the PCDD/F concentrations in human blood was observed. The mean levels found were 43.7 pg I-TEq/g (lipid basis) in 1989 and 20.7 pg I-TEq/g (lipid basis) in 1996/98 median: 42.2 and 19.4]. The reduction to about the half was found for most congeners. Each one-year subset of the collective and the entire collective shows a positive correlation of the PCDD/F blood levels with age for most of the congeners, the sum values and the calculated toxicity equivalents. For statistical evaluation a multiplicative model was used: Concentration = A x Age(B). The correlation is mostly pronounced for lower chlorinated PCDD and for 2,3,4,7,8-PentaCDF. The PCDD/F concentrations in human blood in relation to the year of examination and the age of the subjects can be described by a linear model: I-TEq pg/g (lipid basis)] = 6176 - 3.097 x Year + 0.6482 x Age or by a multiplicative model: I-TEq pg/g(lipid basis)] = 10(89.08-0.04415 x Year + 0.008468 x Age). |
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