Partition coefficients of organic chemicals derived from reversed phase thin layer chromatography: Evaluation of methods and application on phosphate esters,polychlorinated paraffins and some PCB-substitutes |
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Authors: | Lars Renberg Göran Sundström Karin Sundh-Nygård |
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Institution: | Special Analytical Laboratory, National Swedish Environment Protection Board, Wallenberg Laboratory, University of Stockholm, S-106 91 Stockholm, Sweden |
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Abstract: | The application of reversed phase high performance thin layer chromatography has been evaluated for determination of octanol-water partition coefficients (Poct) of organic chemicals. Best correlations between log Poct and RM-values were obtained on a C18-bonded stationary phase using acetone-water or acetonitrile-water mixtures as eluting solvent. The latter mixture is preferred in work with high pressure liquid chromatography. A number of aryl and alkyl/aryl phosphate esters, polychlorinated paraffins and chemicals suggested as PCB-substitutes were chromatographed and the corresponding log Poct-values calculated. Values for the phosphate esters corresponded reasonably well with previously reported data while data for other, often more complex compound mixtures (eg PCB-substitutes), need further evaluation. The use of the chromatographic system for screening purposes in work on environmentally significant data of possible organic pollutants is discussed. |
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