Biological transformation, kinetics and dose-response assessments of bound
musk ketone hemoglobin adducts in rainbow trout as biomarkers of
environmental exposure |
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| Authors: | M A Mottale J H Zimmerman and T W Moy |
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| Institution: | 1. Department of Chemistry and Biochemistry, Baylor University, P.O. Box 97348, Waco, TX 76798, USA
2. U.S. Environmental Protection Agency, National Exposure Research Laboratory, Environmental Sciences Division, 944 East Harmon Ave, Las Vegas, NV 89119, USA |
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| Abstract: | Low levels (ng/g) of musk ketone (MK),used as a fragrance additive in the formulation of personal care products,are frequently detected in the water and other environment.Thus,aquatic organisms can be continuously exposed to MK.In this study,kinetics and dose-response assessments of 2-amino-MK (AMK) metabolite,bound to cysteine-hemoglobin (Hb) in rainbow trout,formed by enzymatic nitro-reduction of MK have been demonstrated.Trout were exposed to a single exposure of 0.010,0.030,0.10,and 0.30 mg MK/g fish... |
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| Keywords: | biotransformation kinetics hemoglobin adducts dose-response nitro musks biomarker fish |
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