Activity and multiple forms of α-L-fucosidase and hexosaminidase in chorion biopsy specimens and some fetal organs |
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Authors: | E M Beyer G Ya Wiederschain |
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Institution: | Institute of Biological and Medical Chemistry, Academy of Medical Sciences of the USSR, Progodin Street 10, Moscow 119121 (U.S.S.R.) |
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Abstract: | It was shown that activities and isoenzyme patterns of x-L-fucosidase and hexosaminidase were similar in biopsy specimens of chorion obtained immediately before induced abortion in normal pregnancy and in chorion tissue itself. A comparative study of isoenzyme patterns of these glycosidases showed their similarity in chorion and human fetal kidney, liver and lungs. The data obtained may be applied to the investigation of the multiple forms of α-L-fucosidase and hexosaminidase in chorion biopsy specimens for the prenatal diagnosis of fucosidosis (α-L-fucosidase deficiency). Tay-Sachs diseases (hexosaminidase A deficiency) and Sandhoff disease (deficiency of hexosaminidase A and B). |
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Keywords: | α-L-Fucosidase Hexosaminidase Multiple forms Chorion biopsy Early prenatal diagnosis |
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