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Ontogeny of fetal liver glucose-6-phosphatase activity
Authors:Thomas J Simpson  Mitsuhiko Koresawa  W Allen Hogge  Wolfgang Holzgreve  Dr Mitchell S Golbus
Institution:Department of Obstetrics, Gynecology and Reproductive Sciences, and Department of Pediatrics, University of California, San Francisco, U.S.A
Abstract:A reliable and sensitive microassay for the measurement of liver glucose-6-phosphatase is described. Human fetal liver was assayed for glucose-6-phosphatase activity from 7.5 to 24 weeks of gestation and was found to have a mean activity of 2.11 nmol per min per mg of protein. This was approximately 30 per cent of the postnatal controls assayed by the same method, but there was no evidence of a change in activity during the gestational period examined. If fetal liver tissue can be reliably obtained, it may be possible to determine a deficiency of glucose-6-phosphatase in fetuses who are at risk.
Keywords:Fetal liver  Glucose-6-phosphatase  Glycogen storage disease Ia  Ontogeny
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