Further examples of trisomy-20 mosaicism in amniotic cell cultures |
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Authors: | M. S. Grewal Dr M. A. C. Ridler J. C. K. Barber |
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Affiliation: | The Kennedy-Galton Centre, Harperbury Hospital, Radlett, Hertfordshire, WD7 9HQ. England |
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Abstract: | Amniotic fluid cultures from two patients showed trisomy-20 mosaicism. No trisomy-20 cells were found in a normal full term infant and in multiple tissue biopsies and fetal blood from a fetus after a termination of pregnancy. No definitive advice is yet possible for parents where trisomy-20 amniotic cell mosaicism is detected. Fetoscopy and fetal blood sampling are of no value and termination of pregnancy is not indicated by empirical evidence. Preferential trophoblastic non-disjunction (Kalousek and Dill, 1983) is discussed as a possible partial explanation for the variable occurrence and distribution of this type of mosaicism. |
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Keywords: | Trisomy 20 Mosaicism Amniocentesis |
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