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Activities of alkaline phosphatase in first trimester chorion biopsy tissue |
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| Authors: | Darryl J. Maxwell Dr Karl Blau Robert D. Johnson Richard J. Lilford |
| Affiliation: | 1. Department of Obstetrics and Gynaecology. University College Hospital, Huntley Street, London WCIE6AU, U.K.;2. Department of Chemical Pathology, Bernhard Baron Memorial Research Laboratories, Queen Charlotte's Maternity Hospital, Goldhawk Road, London W6 0XG, U.K.;3. Department of Obstetrics and Gynaecology, St James's University Hospital, leeds LS9 7TF, U.K. |
| Abstract: | We have determined the activity of alkaline phosphatase in chorionic villous tissue obtained in the first trimester of pregnancy, in order to obtain the normal range of values as a prerequisite for application to the prenatal diagnosis of the rare bone disease hypophosphatasia. The activities found were a combination of intestinal and liver/bone/kidney types; traces of placental type were present in only one sample. |
| Keywords: | Chorionic villi First trimester Alkaline phosphatase Antenatal diagnosis Hypophosphatasia |