Prenatal diagnosis of cystic fibrosis. II. Meconium ileus in affected fetuses |
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| Authors: | F. Muller M. C. Aubry B. Gasser F. Duchatel J. Boué A. Boué |
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| Affiliation: | 1. Laboratory of Biochemistry, Hôspital Ambroise Paré, 92100 Boulogne, France;2. Port-Royal Maternity Hospital, 75014 Paris, France;3. Institute of Pathology, Faculté de Médecine. 67000 Strasbourg. France;4. René Dubos Maternity Hospital, 95000 Pontoise, France;5. Prenatal Biology Research Unit, INSERM U.73, Chateau de Longchamp. 75016 Paris. France |
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| Abstract: | Meconium ileus was the presenting feature of cystic fibrosis in 46 per cent of the couples which have been referred for prenatal diagnosis. In fetuses which have been aborted on the basis of alkaline phosphatase isoenzymes assays, meconium ileus represented the only pathological feature of cystic fibrosis, and was observed in three fourths of the cases. Real-time sonographic examination of fetuses at the time of amniocentesis was able to show an echogenic mass in the abdomen corresponding to the meconium ileus, and thus may afford a complementary means of diagnosis. |
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| Keywords: | Cystic fibrosis Prenatal diagnosis Meconium ileus |
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