Admixture of maternal metaphases in first trimester direct chromosome preparations? |
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| Authors: | P K A Jensen J M Hertz A J Therkelsen |
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| Institution: | Institute of Human Genetics, University of Aarhus, DK-8000 Aarhus C., Denmark |
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| Abstract: | The autoradiographic labelling of different cell types in chorionic villi and decidual tissue was investigated after 3H]-thymidine incorporation in vitro. Although the extent of labelling was found to be lower in decidual than in villus tissue the possibility that direct chromosome preparations may contain maternal metaphases should be considered. The need for careful selection of villi for direct cytogenetic analysis was stressed. |
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| Keywords: | [3H]-thymidine labelling First trimester prenatal diagnosis Direct chromosome analysis Maternal contamination |
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