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Genetic amniocentesis in multiple gestations |
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| Authors: | Karen Filkins MD FACOG Joseph Russo Thomas Brown Susan Schmerler Bernard Searle |
| Institution: | 1. East Carolina University, School of Medicine, Greenville, NC 27834, U.S.A.;2. University of Medicine and Dentistry, New Jersey Medical School, Newark, New Jersey 07107, U.S.A. |
| Abstract: | Thirty-one genetic amniocenteses involving multiple gestations were performed in the genetics unit between 1976 and 1982. Three sets of triplets were included. Precise locations of the sacs were determined using real-time ultrasonography and successful sampling of all sacs was accomplished. Spontaneous abortions occurred in two normal twins and one normal triplet gestation. Two therapeutic abortions were performed for fetal abnormalities. Two cases of discordance for trisomy 21 (one twin and one triplet) were allowed to continue; the twin case terminated at 25 weeks' gestation with neonatal deaths and the triplets are alive and well. |
| Keywords: | Multiple pregnancy Amniocentesis Fetal abnormality Discordance for trisomy 21 |