Limited use of chromosomal markers in prenatal diagnosis |
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| Authors: | Ursula Friedrich Peter K. A. Jensen |
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| Affiliation: | Institute of Human Genetics, Aarhus University, 8000 Aarhus C, Denmark |
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| Abstract: | By aid of fluorescent centromere markers in chromosome No. 3 it could be shown that crossing over in a translocation quadrivalent had occurred on two occasions in a father who is carrier of a 3/5 translocation. This case demonstrates that marker chromosomes cannot always be used to trace the parental origin of structurally abnormal chromosomes. |
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| Keywords: | Fluorescent centromere markers 3/5 translocation Crossing over in translocation quadrivalent |
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