Rh isoimmunization following genetic amniocentesis |
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| Authors: | Mitchell S Golbus MD John D Stephens Howard M Cann John Mann Paul A Hensleigh |
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| Institution: | 1. Departments of Obstetrics, Gynecology and Reproductive Sciences and of Pediatrics, University of California San Francisco;2. Pediatrics, Gynecology and Obstetrics, and Genetics, Stanford University School of Medicine;3. and Genetics, Kaiser Permanente Medical Care Program, U.S.A. |
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| Abstract: | A series of 8009 genetic amniocenteses were retrospectively examined to evaluate the relationship of the procedure to Rh isoimmunization. Of the 615 Rh negative women giving birth to Rh positive infants and estimated to be at risk, thirteen (2·1 per cent) were sensitized subsequent to the amniocentesis. Eleven of the sensitizations occurred early in the programs, and a combination of experience and ultrasound performed concurrently with the amniocentesis appear to have reduced the risk of isoimmunization to that of control data from the literature. |
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| Keywords: | KEY WORDS Amniocentesis Rh isoimmunization |
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