Pathological alterations typical of human Tay-Sachs disease, in the retina of a deep-sea fish |
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Authors: | L Fishelson Yacov Delarea Bella S Galil |
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Institution: | (1) Department of Zoology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel e-mail: fishelv@ccsg.tau.ac.il Fax: +972-3-6409403, IL;(2) Electron Microscopy Unit, George S. Wise Faculty of Life Science, Tel Aviv University, Tel Aviv 69978, Israel, IL;(3) Israel Oceanographic and Limnological Research Laboratory, National Institute of Oceanography, POB. 8030, Haifa 31080, Israel, IL |
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Abstract: | Micrographs of retinas from the deep-sea fish Cataetyx laticeps revealed visual cells containing membranous whorls in the ellipsoids of the inner segments resulting from stretching and
modifications of the mitochondria membranes and their cristae. These pathological structures seem to be homologous to the
whorls observed in retinas of human carriers of Tay-Sachs disease. This disease, a genetic disorder, is found in humans and
some mammals. Our findings in fish suggest that the gene responsible can be found throughout the vertebrate evolutionary tree,
possibly dormant in most taxa.
Received: 20 April 2000 / Accepted in revised form: 16 June 2000 |
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