Endocrine modulation, inhibition of ovarian development and hepatic alterations in rainbow trout exposed to polluted river water |
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Authors: | Luigi Viganò Emilio Benfenati Alessandra Cevasco Alberta Mandich |
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Institution: | a Water Research Institute, National Council of Research, Brugherio, Milan, Italy b Mario Negri Institute, Laboratory of Environmental Chemistry and Toxicology, Milan, Italy c Department of Environmental, Experimental and Applied Biology, University of Genoa, Genoa, Italy |
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Abstract: | Under laboratory conditions, female rainbow trout were exposed to graded concentrations of water from the River Lambro, a polluted tributary of the River Po, and to the effluent of a large wastewater treatment plant which flows into the River Lambro. In field exposures, trout were held in cages in the River Po upstream and downstream from the confluence of the River Lambro. After 10-day (laboratory) and 30-day (laboratory and field) exposures, trout were examined for several chemical, biochemical and histological endpoints. The results indicated that exposure to complex mixtures of chemicals, including estrogen receptor agonists, aryl-hydrocarbon receptor agonists, and probably antiandrogens, had occurred. Exposure altered the plasma levels of 17β-estradiol and testosterone, and some treatments also enhanced the activity of hepatic ethoxyresorufin O-deethylase. Gonadal histology showed varying levels of degenerative processes characterised by oocyte atresia, haemorrhages, melano-macrophage centres (MMCs), and oogonia proliferation. Liver histology showed less severe effects. |
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Keywords: | Estrogen receptor agonists Aryl-hydrocarbon receptor agonists Antiandrogens Plasma hormones Ovarian atresia Oogonia proliferation |
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