| PBNA及其同分异构体PANA在小鼠ICR系中致癌性的比较研究 |
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| 引用本文： | 王达,曾若望,王蘅文.PBNA及其同分异构体PANA在小鼠ICR系中致癌性的比较研究[J].环境科学学报,1983,3(3):257-261. |
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| 作者姓名： | 王达 曾若望 王蘅文 |
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| 作者单位： | 中国科学院上海细胞生物研究所
(王达，曾若望)，中国科学院上海细胞生物研究所(王蘅文) |
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| 摘 要： | 对幼ICR雄性小鼠多次皮下注射PANA或它的同分异构体PANA的二甲基亚砜溶液,总剂量432mg,实验周期在10个月左右时均能引起显著高于对照组动物的恶性肿瘤.PANA诱发小鼠肿瘤可能存在剂量——反应关系.PBNA和PANA诱发肿瘤率相似,均以肺癌为主,但明显有不同的亲器官性.实验结果提示二者的致癌机理可能不是由于形成相应的萘胺所致.PANA对动物有致癌性,在国内外尚未见有报道.
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| 收稿时间： | 1982/11/15 0:00:00 |
A COMPARATIVE STUDY ON CARCINOGENIC ACTIVITIES OF PBNA AND ITS ISOMER PANA IN ICR MICE |
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| Wang D,Zeng Ruowang and Wang Hengwen.A COMPARATIVE STUDY ON CARCINOGENIC ACTIVITIES OF PBNA AND ITS ISOMER PANA IN ICR MICE[J].Acta Scientiae Circumstantiae,1983,3(3):257-261. |
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| Authors: | Wang D Zeng Ruowang and Wang Hengwen |
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| Institution: | Shanghai Institute of Cell Biology, Academia Sinica,Shanghai Institute of Cell Biology, Academia Sinica and Shanghai Institute of Cell Biology, Academia Sinica |
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| Abstract: | Repeated subcutaneous injection of technical PBNA, technical PANA and chemically pure PANA in DMSO solution into young adult male ICR mice induced malignant tumors 34.6%, 46.6% and 52.2%, respectively at the end of IQth experimental month with a total dose of 432mg given to each animal. No malignant tumors appeared in controls using DMSO. PANA seemed to show dose-response relationship in tumor initiation. Both tend to induce pulmonary carcinomas, with PANA also to induce carcinomas and hemangio-endotheliomas of kidneys. |
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