Exposure to organochlorines and mercury through fish and marine mammal consumption: Associations with growth and duration of gestation among Inuit newborns |
| |
| Institution: | 1. School of Psychology, Laval University and CHUQ Research Center, Quebec, Canada;2. Department of Social and Preventive Medicine, Laval University and CHUQ Research Center, Quebec, Canada;3. Department of Psychiatry & Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, USA;1. Institute of Food Safety, Animal Health and Environment ?BIOR”, Lejupes iela 3, Riga LV-1076, Latvia;2. University of Latvia, Department of Chemistry, Jelgavas iela 1, Riga LV-1004, Latvia;1. Centre de Recherche du Centre Hospitalier Universitaire de Québec, Québec, Québec, Canada;2. Centre de Recherche en Neuropsychologie et Cognition, Département de Psychologie, Université de Montréal, Montréal, Québec, Canada;3. Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA;4. Université Laval, Québec, Québec, Canada;1. Department of Environmental Health, Harvard School of Public Health, 401 Park Drive, HSPH-BWH-301W, Boston, MA 02215, USA;2. Institute of Environmental Medicine, Karolinska Institutet, Box 210, Nobelsväg 13, Solna 171 77, Sweden;3. Centre for Studies on Human Stress, Research Center of the Mental Health Institute, 7401 Rue Hochelaga, Montreal, Quebec, H1N 3M5, Canada;4. Etholabs, School of Psychoeducation, University of Montreal, C. P. 6128, succursale Centre-ville, Montreal, Quebec, H3C 3J7, Canada;5. Département de psychologie, Université du Québec à Montréal, 320 Sainte-Catherine Est Pavillon J.A. De Sève, local DS5775, Montreal, Quebec H2X 1L7, Canada;6. INSERM U1085, Université Rennes I, 263 Avenue du Général Leclerc, 35042 Rennes, France;7. Department of Occupational and Environmental Health, School of Public Health, Université de Montréal, 2375 ch. de la Cote-Sainte-Catherine, Montreal, Quebec, H3T 1A8, Canada;8. Université de Montréal Public Health Research Institute, Université de Montréal, 7101 avenue du Parc, office 3187-03, Montreal, Quebec, H3N 1X9, Canada;9. Centre de recherche du CHU de Québec, Université Laval, 2875 Laurier, Quebec, Quebec G1V 2M2, Canada |
| |
| Abstract: | BackgroundSeveral studies have reported negative associations of polychlorinated biphenyls (PCBs), hexachlorobenzene (HCB) and mercury (Hg) with duration of gestation and fetal growth in fish eating populations. Docosahexaenoic acid (DHA) from fish, seafood and marine mammal intake has been reported to be positively related with pregnancy duration and fetal growth. So far, it remains unclear, however, if the associations of environmental contaminants (ECs) with growth are direct or mediated through their relation with the duration of gestation and the degree to which DHA intake during pregnancy attenuates the negative association of ECs with fetal growth.ObjectivesTo investigate direct and indirect associations of in utero exposure to ECs with fetal growth and pregnancy duration while taking into account the possible positive effects of DHA.MethodsPregnant Inuit women (N = 248) from Arctic Quebec were recruited and cord blood samples were analyzed for PCBs, HCB, Hg and DHA. Anthropometric measurements were assessed at birth. Path models were used to evaluate direct and indirect associations.ResultsCord concentrations of PCB 153, HCB and Hg were significantly associated with shorter duration of pregnancy (β varying from ? 0.17 to ? 0.20, p < 0.05). Path models indicated that the associations of PCBs, HCB and Hg with reduced fetal growth (β varying from ? 0.09 to ? 0.13, p < 0.05) were mediated through their relations with shorter gestation duration. Cord DHA was indirectly related to greater growth parameters (β varying from 0.17 to 0.20, p < 0.05) through its positive association with gestation duration.ConclusionPrenatal exposure to ECs was associated with reduced gestation duration, which is a recognized determinant of fetal growth. DHA intake during pregnancy appeared to have independent positive association with fetal growth by prolonging gestation. Whether these associations are causal remains to be elucidated. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
