Associations between blood persistent organic pollutants and 25-hydroxyvitamin D3 in pregnancy |
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| Affiliation: | 1. Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia, Spain;2. Hospital del Mar Medical Research Institute (IMIM), Barcelona, Catalonia,Spain;3. CIBER in Epidemiology and Public Health (CIBERESP), Spain;4. Center for Public Health Research (CSISP), Valencia, Spain;5. University of Valencia, Valencia, Spain;6. Subdirección de Salud Pública de Gipuzkoa, Department of Health of the Basque Government, San Sebastian, Spain;7. BIODONOSTIA Health Research Institute, San Sebastian, Spain;8. Clinical Chemistry Unit, Public Health Laboratory of Bilbao, Euskadi, Spain;9. Laboratorio de Salud Pública de Guipúzcoa, San Sebastián, Spain;10. Unit of Molecular Cancer Epidemiology, Universitary Institute of Oncology of Asturias (IUOPA), Department of Preventive Medicine and Public Health, University of Oviedo, Asturias, Spain;11. Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Barcelona, Catalonia, Spain;12. University Pompeu Fabra, Barcelona, Catalonia, Spain;1. Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research and Cellular Imaging Section, Institute for Cell Engineering, the Johns Hopkins University School of Medicine, Baltimore, MD, USA;2. Department of Medicine, Division of Cardiology, Washington University Medical School, St. Louis, MO, USA;3. Philips Healthcare, Cleveland, OH, USA;4. Philips Research, Hamburg, Germany;1. Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA;2. Center for Thrombosis and Hemostasis, Universitätsmedizin, Johannes Gutenberg University, Mainz, Germany;3. UMR CNRS 7213 Laboratoire de Biophotonique et Pharmacologie, Université de Strasbourg, Illkirch, France;1. Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA;2. Department of Epidemiology and of Pharmacology and Toxicology, Geisel School of Medicine, Dartmouth College, Hanover, NH 03756, USA;3. Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA;1. Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari “Aldo Moro”, via E. Orabona 4, 70126 Bari, Italy;2. Pharmacognosy Research Laboratories, Medway School of Science, University of Greenwich, Chatham-Maritime, Kent ME4 4TB, UK |
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| Abstract: | Persistent organic pollutants (POPs) are suggested to contribute to lower vitamin D levels; however, studies in humans are scarce and have never focused on pregnancy, a susceptibility period for vitamin D deficiency. We investigated whether serum levels of POPs were associated with circulating 25-hydroxyvitamin D3 [25(OH)D3] concentration in pregnancy. Cross-sectional associations of serum concentrations of eight POPs with plasma 25(OH)D3 concentration were analyzed in 2031 pregnant women participating in the Spanish population-based cohort INfancia y Medio Ambiente (INMA) Project. Serum concentrations of POPs were measured by gas chromatography and plasma 25(OH)D3 concentration was measured by high-performance liquid chromatography in pregnancy (mean 13.3 ± 1.5 weeks of gestation). Multivariable regression models were performed to assess the relationship between blood concentrations of POPs and 25(OH)D3. An inverse linear relationship was found between serum concentration of PCB180 and circulating 25(OH)D3. Multivariate linear regression models showed higher PCB180 levels to be associated with lower 25(OH)D3 concentration: quartile Q4 vs. quartile Q1, coefficient = − 1.59, 95% CI − 3.27, 0.08, p trend = 0.060. A non-monotonic inverse relationship was found between the sum of predominant PCB congeners (PCB 180, 153 and 138) and 25(OH)D3 concentration: coefficient (95% CI) for quartile Q2 vs. Q1 [− 0.50 (− 1.94, 0.94)], quartile Q3 vs. Q1 [− 1.56 (− 3.11, − 0.02)] and quartile Q4 vs. Q1 [− 1.21 (− 2.80, 0.38)], p trend = 0.081. No significant associations were found between circulating 25(OH)D3 and serum levels of p,p′-DDE, p,p′-DDT, HCB, and ß-HCH. Our results suggest that the background exposure to PCBs may result in lower 25(OH)D3 concentration in pregnant women. |
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