Responses of antioxidant status and Na+–K+-ATPase activity in gill of rainbow trout,Oncorhynchus mykiss,chronically treated with carbamazepine |
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| Institution: | 1. University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, Research Institute of Fish Culture and Hydrobiology, Zatisi 728/II, 389 25 Vodnany, Czech Republic;2. Umea University, Department of Chemistry, SE-90187 Umea, Sweden;1. Department of Medical Biochemistry, Dr. Alm P-G, Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, Tamil Nadu 600113, India;2. Department of Pathology, Dr. ALM P-G, Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, Tamil Nadu 600113, India;1. Institute of Clinical Molecular Biology, Christian-Albrechts University Kiel, Germany;2. Alfred-Wegener-Institute Helmholtz Center for Polar and Marine Research, Bremerhaven, Germany;1. State Key Laboratory of Ecological Animal Husbandry and Environment Veterinary Medicine, College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, shanxi, China;2. Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture, Guangxi Acedemy of Fishery Science, Nanning, 530021, Guangxi, China;1. Laboratory of Aquatic Toxicology, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Unidad Profesional Adolfo López Mateos, AV. Wilfrido Massieu S/n y cerrada Manuel Stampa, Col. Industrial Vallejo, Ciudad de México, CP, 07700, Mexico;2. Laboratory of Environmental Toxicology, Facultad de Química, Universidad Autónoma del Estado de México, Paseo Colón intersección Paseo Tollocan S/n. Col. Residencial Colón, 50120, Toluca, Estado de México, Mexico;3. Cátedra CONACYT, Laboratory of Aquatic Toxicology, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Unidad Profesional Adolfo López Mateos, AV. Wilfrido Massieu S/n y cerrada Manuel Stampa, Col. Industrial Vallejo., Ciudad de México, CP, 07700, Mexico;1. Biology Department, University of Aveiro, 3810-193 Aveiro, Portugal;2. Chemistry Department & CESAM, University of Aveiro, 3810-193 Aveiro, Portugal;3. BAM Federal Institute for Materials Research and Testing, Richard-Willstaetter -Str. 11, D-12489 Berlin, Germany;4. Biology Department & CESAM, University of Aveiro, 3810-193 Aveiro, Portugal |
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| Abstract: | In recent years, chemical pollution by the residual pharmaceuticals has been increasingly important issue due to its widely present in the aquatic environment. However, the toxicological effects of residual pharmaceuticals on fish have not been adequately researched. The aim of this work is to investigate the toxic effect of CBZ, an anticonvulsant drug commonly present in aquatic environment, on antioxidant status and Na+–K+-ATPase in gill of rainbow trout exposed to sublethal CBZ (1.0 μg L?1, 0.2 mg L?1 and 2.0 mg L?1) for 7, 21 and 42 d. After prolonged exposure of CBZ at higher test concentration (0.2 or 2.0 mg L?1), oxidative stress was apparent as reflected by the significant higher LPO and CP levels in fish gill, as well as the significant inhibition of antioxidant enzymes activities including SOD, CAT, GR and GPx. Besides, reduced glutathione level and Na+–K+-ATPase activity were significantly lower than those of the control after 42 d of exposure to CBZ at higher test concentration (0.2 or 2.0 mg L?1). The results of this study indicate that chronic exposure of CBZ has altered multiple physiological indices in fish gill; however, before those parameters are used as special biomarkers for monitoring residual pharmaceuticals in aquatic environment, more detailed experiments in laboratory need to be performed in the future. |
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