Vitamin B12 als biologisch aktive Modellsubstanz |
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Authors: | Boles?aw Zagalak |
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Institution: | 1. Chemisches Laboratorium, Universit?ts-Kinderklinik, CH-8032, Zürich
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Abstract: | A critical review on corrinoid biochemistry and physiology is presented. This includes: chemical synthesis of biologically important organocorrinoids and the correlation between their structures and coenzymatic activity; forms, distribution and transport of physiologically active corrinoids; methylcobalamin- and adenosylcobalamin-dependent enzymatic reactions and their physiological functions; and steric course of the adenosylcobalamin-dependent enzymatic rearrangements. Special attention is paid to the mechanisms of adenosylcobalamin-dependent enzymatic reactions. |
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