| 雌酮的氯化产物及其内分泌干扰作用活性 |
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| 引用本文： | 程水杰,胡建英.雌酮的氯化产物及其内分泌干扰作用活性[J].环境化学,2004,23(1):71-74. |
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| 作者姓名： | 程水杰 胡建英 |
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| 作者单位： | 北京大学环境学院,北京,100871;北京大学环境学院,北京,100871 |
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| 基金项目： | 国家杰出青年科学基金项目( 4992 5 1 0 3 )，基金委优秀创新群体项目( 40 0 2 41 0 1 )，环保“863”项目 ( 2 0 0 1AA6460 1 0 5 ) |
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| 摘 要： | 利用固相萃取-LC/ESI-MS分析测定雌酮及其在氯气消毒过程中产生的副产物，结果表明，雌酮容易和次氯酸发生反应，并检出了包括一氯雌酮、二氯雌酮在内的4种副产物．用酵母双杂交方法对副产物的内分泌干扰活性进行了测试，发现副产物也具有内分泌干扰作用．
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| 关 键 词： | 雌酮 内分泌干扰物质 酵母双杂交 |
PRODUCTS OF AQUEOUS CHLORINATION OF ESTRONE AND THEIR ESTROGENIC ACTIVITY |
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| CHENG Shui jie,HU Jian ying.PRODUCTS OF AQUEOUS CHLORINATION OF ESTRONE AND THEIR ESTROGENIC ACTIVITY[J].Environmental Chemistry,2004,23(1):71-74. |
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| Authors: | CHENG Shui jie HU Jian ying |
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| Abstract: | Because estrone elicits strong estrogenic disrupting action,its potential risk has become one of important environmental issues.In this study,the experimental results acquired by analyzing estrone and its products of aqueous chlorination using SPE LC/ESI MS method indicate that estrone is apt to react with HClO,and the four by products including monochloro estrone and dichloro estrone were identified.Besides,the estrogenic activity of aqueous chlorination solution of estrone at 10,30,180 and 420min were detected by using yeast two hybrid system,and the results show that the by products of estrone chlorination also elicit estrogenic activities. |
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| Keywords: | estrone endocrine disruptors yeast two hybrid |
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