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低浓度2,4-DCP对鲫鱼肝脏抗氧化防御系统的影响
引用本文:张景飞,王晓蓉,沈骅. 低浓度2,4-DCP对鲫鱼肝脏抗氧化防御系统的影响[J]. 中国环境科学, 2003, 23(5): 0-0
作者姓名:张景飞  王晓蓉  沈骅
作者单位:南京大学环境学院,污染控制与资源化研究国家重点实验室,江苏,南京,210093
基金项目:高等学校博士点专项基金资助项目(2000028424),国家自然科学基金资助项目(20237010)
摘    要: 采用室内模拟方法,以2,4-二氯苯酚(2,4-DCP)和小鲫鱼(Carassius auratus)为实验材料,研究了0.1mg/L 2,4-DCP在不同暴露期内对鲫鱼肝脏抗氧化防御系统的影响.结果表明,过氧化氢酶(CAT)、超氧化物歧化酶(SOD)及氧化型谷胱甘肽(GSSG)对2,4-DCP非常敏感,在暴露第2天就受到极显著的诱导或抑制(P<0.01);还原型谷胱甘肽(GSH)含量总体上被抑制;谷胱甘肽还原酶(GR)活性整体上呈现轻微诱导趋势谷胱甘肽过氧化物酶(Se-GPx)活性先受抑制后被诱导;谷胱甘肽硫转移酶(GST)的活性先被诱导,后降低到对照组水平.上述肝脏抗氧化酶指标可作为水生生态系统中2,4-DCP污染的生物监测指标.

关 键 词:2,4-二氯苯酚  暴露  鲫鱼  抗氧化防御系统
文章编号:1000-6923(2003)05-0531-04
收稿时间:1900-01-01;
修稿时间:2003-02-11

Influence of low-level 2,4-DCP on the antioxidant defense system in livers of Carassius auratus
ZHANG Jing-fei,WANG Xiao-rong,SHEN Hua. Influence of low-level 2,4-DCP on the antioxidant defense system in livers of Carassius auratus[J]. China Environmental Science, 2003, 23(5): 0-0
Authors:ZHANG Jing-fei  WANG Xiao-rong  SHEN Hua
Abstract:Adopting indoor simulation technique with 2,4-Dichlorophenol (2,4-DCP) and Carassius auratus as experimental materials to study for the first time the influence of 0.1mg/L 2,4-DCP on the antioxidant defense system in the liver of the fish. Catalase (CAT), superoxide dismutase (SOD) and oxidized glutathione (GSSG) were very sensitive to 2,4-DCP; and induced or inhibited very significantly at the second day of exposure (P<0.01). The contents of reduced glutathione (GSH) were inhibited on the whole. The activities of glutathione reductase (GR) tended to be induced slightly on the whole. The activities of selenium-dependent glutathione peroxidase (Se-GPx) were inhibited first and then induced. The activities of glutathione S-transferase (GST) were induced first and then lowered to the control level. These hepatic antioxidant indices mentioned above could be considered as biological monitoring indices of 2, 4-DCP pollution in aquatic ecosystems.
Keywords:Dichlorophenol (2  4-DCP)  exposure  Carassius auratus  antioxidant defense system
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