A Multiscale Approach for Assessing the Interactions of Environmental and Biological Systems in a Holistic Health Risk Assessment Framework |
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Authors: | Panos G Georgopoulos |
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Institution: | (1) Computational Chemodynamics Laboratory (CCL), Environmental and Occupational Health Sciences Institute (EOHSI), UMDNJ Robert Wood Johnson Medical School and Rutgers University, 170 Frelinghuysen Road – Room 308, Piscataway, NJ 08854, USA |
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Abstract: | Advances in computing processing power and in availability of environmental and biological data have allowed the development
and application of comprehensive modeling systems that utilize a holistic, integrated, approach for assessing the interactions
of environmental and biological systems across multiple scales of spatiotemporal extent and biological organization. This
approach allows mechanism-based environmental health risk assessments in a person-oriented framework, which accounts for simultaneous
exposures to contaminants from multiple media, routes, and pathways. The conceptual basis and example applications of the
Modeling ENvironment for TOtal Risk (MENTOR), and the DOse–Response Information ANalysis system (DORIAN) are presented. |
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Keywords: | Comprehensive modeling systems DORIAN MENTOR Environmental health Risk assessments Exposures to mixtures |
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