| 不同pH值下对发光菌的毒性及QSAR研究 |
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| 引用本文： | 于瑞莲,胡恭任.不同pH值下对发光菌的毒性及QSAR研究[J].环境科学与技术,2005,28(4):20-22. |
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| 作者姓名： | 于瑞莲 胡恭任 |
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| 作者单位： | 华侨大学材料科学与工程学院,泉州,362021;华侨大学材料科学与工程学院,泉州,362021 |
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| 基金项目： | 华侨大学科研资金资助项目(02HZR01) |
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| 摘 要： | 测定了11种苯酚类化合物在不同pH下对发光菌的急性毒性(15minEC50。)。应用两种理化参数logP和pKa对毒性数据进行了定量构效关系(QSARs)研究,并在此基础上初步探讨了苯酚类化合物的毒性机制。结果表明,苯酚类化合物对发光菌的毒性随pH的升高而减小,这与不同pH下苯酚类化合物的电离程度有关。相同pH下,苯酚类化合物的毒性随取代基团的种类、个数及取代位置而不同。苯酚类化合物属于极性麻醉(麻醉Ⅱ型)化合物,毒性可用logP和pKa来联合描述。
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| 关 键 词： | 苯酚类化合物 pH值 发光菌 15min-EC50 QSAR 毒性机制 |
| 文章编号： | 1003-6504(2005)04-0020-03 |
| 修稿时间： | 2004年4月7日 |
Toxicity of Phenols to Photobacterium Phosphoreum at Different pH and QSAR |
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| YU Rui-lian,HU Gong-ren.Toxicity of Phenols to Photobacterium Phosphoreum at Different pH and QSAR[J].Environmental Science and Technology,2005,28(4):20-22. |
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| Authors: | YU Rui-lian HU Gong-ren |
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| Abstract: | Acute toxicity (15min-EC50) of 11 phenols to photo-bacterium phosphoreum was measured at different pH. Quantitative structure-activity relationships (QSARs) were established using two physico-chemical parameters logP and pKa, based on which the toxic mechanisms of anilines were prelimi-narily discussed. Results showed that the acute toxicity of phenols decreased with pH,which is related to the ionization degree of phenols. The toxicity of phenols varies with the kind,number and position of substituents at the same pH. Phenols are polar narcosis (narcosis II) compounds, whose toxicity to photobacterium phosphoreum can be described by logP and pKa. |
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| Keywords: | phenols pH photobacterium phosphoreum lSmin-EC5o t QSAR toxicity mechanism |
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