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Reproductive toxicity assessment of surface water of the Tai section of the Yangtze River, China by in vitro bioassays coupled with chemical analysis |
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| Authors: | Wang Xiaoyi Wu Jiang Hao Yingqun Zhu Bingqing Shi Wei Hu Guanjiu Han Xiaodong Giesy John P Yu Hongxia |
| Affiliation: | a The State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210093, PR China b Jiangsu Academy of Environmental Science, Nanjing 210036, PR China c Laboratory of Immunology and Reproductive Biology, School of Medicine, Nanjing University, Nanjing 210093, PR China d The Environmental Monitoring Center of Jiangsu Province, Nanjing 210036, PR China e State Key Laboratory in Marine Pollution, Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong SAR, PR China f Department of Veterinary Biomedical Sciences and Toxicology Centre, University of Saskatchewan, Canada g Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia |
| Abstract: | Reproductive toxicity of organic extracts of the surface water from the Tai section of the Yangtze River was assessed by in vitro cytotoxity assays and selected persistent organic pollutants including PCBs, OCPs and PAHs were quantified by instrumental analysis. Eleven of the US EPA priority PAHs were detected. Individual PAHs were found to range from 0.7 to 20 ng/L. Concentrations of BaP did not exceed the national drinking water source quality standard of China. However, a 286-fold concentrated organic extract induced significant reproductive toxicity in adult male rats. The morphology of cells, MTT assay and LDH release assay were all affected by exposure to the organic extracts of water. The results of the reproductive toxicity indicated that PAHs posed the greatest risk of the chemicals studied. The compounds present in the water could be bioconcentrated and result in adverse effects. |
| Keywords: | Surface water Reproductive toxicity Persistent organic pollutants |
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