Structure of the major metabolite of 1-propyl-3,5-diethyl-6-chlorouracil in rabbits |
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| Authors: | R Kaul B Hempel |
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| Institution: | Research Laboratories, Pharmaceuticals Robugon GmbH Postfach 266, D - 7300 Esslingen, West Germany |
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| Abstract: | The major metabolite of 1-propyl-3,5-diethyl-6-chlorouracil has been identified as 6,8-diethyl-2-methyl-tetrahydrooxazolo3,2-c]pyrimidine-5,7(4H,6H)-dione. The biotransformation to this bicyclic barbituric acid derivative takes place via substitution of the chlorine by ß- and not by α-hydroxy group of the intermediate hydroxypropane. |
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