Biokonzentration von persistenten superlipophilen Chemikalien in aquatischen Organismen |
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Authors: | H J Geyer C E W Steinberg A Kettrup |
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Institution: | 1. GSF-Institut für ?kologische Chemie, Ingolst?dter Landstra?e 1, D-W-8042, München-Neuherberg
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Abstract: | According to generally accepted theory, persistent superlipophilic chemicals with logn-octanol/water partitioning coefficient (log Kow) >6 and molecular sizes >9,5 Å, such as octachlorodibenzo-p-dioxin, decachlorobiphenyl, Mirex etc., do not significantly bioconcentrate in aquatic organisms from ambient water. In the light of new results and considerations, this hypothesis has to be revised. The most convincing argument against this hypothesis is that in all bioconcentration experiments with superlipophilic chemicals compound concentrations have been applied which exceeded water solubility by several orders of magnitude. In this paper we describe various methods how to determine bioconcentration (BCF) factors of superlipophilic compounds. As exemplified with octachlorodibenzo-p-dioxin and Mirex, BCF values evaluated by this means match well those calculated by QSARs for fish and mussels based on log Kow and water solubility as well. As expected these BCF values exceed previous ones by several orders of magnitude. As practical consequences, we recommend for BCF evaluations of superlipophilic chemicals: - flow-through systems, kinetic method (OECD guideline No 305 E)
- ambient concentrations≤water solubility.
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