Metabolism of a nonylphenol isomer by Sphingomonas sp. strain TTNP3 |
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Authors: | P F X Corvini M Elend J Hollender R Ji A Preiss R Vinken A Schäffer |
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Institution: | (1) Department of Biology V—Environmental Biology and Chemodynamics, RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany;(2) Fraunhofer ITEM, NikolaiFuchsStrasse 1, 30625 Hannover, Germany;(3) Institute of Hygiene and Environmental Health, University Hospital, RWTH Aachen University, Pauwelstrasse 30, 52074 Aachen, Germany |
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Abstract: | For elucidation of the metabolism of the endocrine disruptor nonylphenol by Sphingomonas sp. strain TTNP3, the degradation of an isomer of nonylphenol, 4(2 ,6 -dimethyl-2 -heptyl)-phenol, has been studied. As in the case of 4(3 ,5 -dimethyl-3 -heptyl)-phenol, the metabolism of this nonylphenol isomer leads to the formation of the NIH-shifted product 2(2 ,6 -dimethyl-2 -heptyl)-1,4-benzenediol (NIH: National Institute of Health), but also to the alkoxy derivative 4(2 ,6 -dimethylheptan-2 -yloxy)phenol as additional metabolite. To the best of our knowledge, this is the first report describing the formation of alkoxyphenol as a degradation product of nonylphenol. Additionally, these results provide for the first time evidence for slight differences in the biodegradation of the isomers of nonylphenol. |
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Keywords: | Nonylphenol Single isomer Metabolites Alkoxyphenol Degradation Sphingomonas Endocrine disruptor |
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