|
|||||
|
|
Low dose effects and non-monotonic dose responses for endocrine active chemicals: Science to practice workshop: Workshop summary |
|
| Authors: | Claire Beausoleil Jean-Nicolas Ormsby Andreas Gies Ulla Hass Jerrold J Heindel Marie Louise Holmer Pia Juul Nielsen Sharon Munn Gilbert Schoenfelder |
| Institution: | 1. French Agency for Food, Environmental and Occupational Health & Safety (ANSES), 27-31 Avenue du Général Leclerc, 94701 Maisons-Alfort Cedex, France;2. The Federal Environment Agency (UBA), Umweltbundesamt Bismarckplatz 1, 14193 Berlin, Germany;3. National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, 2860 Søborg, Denmark;4. National Institute of Environmental Health Sciences/National Institutes of Health, 111 T. W. Alexander Drive, Research Triangle Park, NC 27709, United States;5. Danish Ministry of the Environment, Environmental Protection Agency, Strandgade 29, 1401 Copenhagen K, Denmark;6. European Commission, Joint Research Centre, Via E. Fermi 2749, 21027 Ispra, VA, Italy;g Charite Universitatmedizin, Campus Charité Mitte, Charitéplatz 1, 10117 Berlin, Germany |
| Abstract: | A workshop was held in Berlin September 12–14th 2012 to assess the state of the science of the data supporting low dose effects and non-monotonic dose responses (“low dose hypothesis”) for chemicals with endocrine activity (endocrine disrupting chemicals or EDCs). This workshop consisted of lectures to present the current state of the science of EDC action and also the risk assessment process. These lectures were followed by breakout sessions to integrate scientists from various backgrounds to discuss in an open and unbiased manner the data supporting the “low dose hypothesis”. While no consensus was reached the robust discussions were helpful to inform both basic scientists and risk assessors on all the issues. There were a number of important ideas developed to help continue the discussion and improve communication over the next few years. |
| Keywords: | ANSES French Agency for Food Environmental and Occupational Health & Safety BfR Bundesinstitut fü r Risikobewertung German Federal Institute for Risk Assessment BPA bisphenol A EAC endocrine active compound EDC endocrine disrupting chemical EFSA European Food Safety Authority EPA US Environmental Protection Agency FDA US Food and Drug Administration GLP Good Laboratory Practices NGO non-governmental organization NIEHS National Institutes of Environmental Health Sciences NMDR non-monotonic dose response NMDRC non-monotonic dose response curve NOAEL no observed adverse effect level NTP US National Toxicology Program OECD Organization for Economic Cooperation and Development |
| 本文献已被 ScienceDirect 等数据库收录！ | |