Synaptic Cell Adhesion Proteins and Synaptogenesis in the Mammalian Central Nervous System |
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Authors: | N Brose |
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Institution: | Max-Planck-Institut für Experimentelle Medizin, AG Molekulare Neurobiologie, Hermann-Rein-Strasse 3, D-37075 G?ttingen, Germany e-mail: brose@mail.mpiem.gwdg.de Tel.: +49-551-3899725 Fax: +49-551-3899753, DE
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Abstract: | 12 nerve cells with up to 1015 synapses. In principle, synaptogenesis takes place in two consecutive steps that are most likely mediated by cell adhesion
molecules. First, an arriving axonal growth cone identifies its appropriate partner cell, creating an initial contact, and,
second, specific axonal and dendritic protein components are recruited to this initial contact site, forming a functional
synapse. Three cell adhesion systems have recently been shown to be specifically enriched at synaptic contacts: the cadherin/catenin
system, the cadherinlike neuronal receptors, and the β-neurexin/neuroligin system. Components of all three cell adhesion systems
have been localized to synaptic contacts using immunogold electron microscopy but are also present outside of synapses. The
present short review discusses the possible role of these synaptic cell adhesion molecules in synaptogenesis. |
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