| 细胞凋亡的线粒体途径调控 |
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| 引用本文： | 高方远,陆贤军,任光俊. 细胞凋亡的线粒体途径调控[J]. 应用与环境生物学报, 2004, 10(2): 251-255 |
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| 作者姓名： | 高方远 陆贤军 任光俊 |
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| 作者单位： | 1. 四川省农业科学院作物研究所,成都,610066;四川大学生命科学学院,成都,610064
2. 四川省农业科学院作物研究所,成都,610066 |
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| 摘 要： | 细胞凋亡是近年来研究的一个热点问题，涉及到细胞内许多复杂的生化过程．线粒体是真核生物能量和代谢的中心，也是细胞凋亡信号传导途径中起关键调节作用的细胞器，对细胞凋亡的线粒体途径调控机制进行研究具有重要意义．本文综述了细胞凋亡过程中线粒体途径的信号传导及其调控机制、线粒体对细胞凋亡信号的反应、细胞凋亡过程中线粒体功能丧失几方面的研究进展．图1参43
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| 关 键 词： | 细胞凋亡 线粒体 调控 细胞程序化死亡 细胞器 信号传导 蛋白 |
| 修稿时间： | 2003-06-16 |
REGULATION OF MITOCHONDRIA IN APOPTOSIS |
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| Abstract: | Apoptosis is the capacity of a cell to undergo programmed cell death, which involves many cellular biochemical e-vents. Mitochondria are the bioenergetic and metabolic center of eukaryotic cell. During apoptosis, many key events are related to mitochondria. The central roles for mitochondria as the orchestrators of apoptosis have been firmly established in recent years. This review summarizes the recent data on execution and regulation of mitochondrial apoptotic signals; mitochondrial response to apoptotic signals and loss of mitochondria functions during apoptosis. Fig 1, Ref 43 |
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| Keywords: | programmed cell death apoptosis mitochondria excution of signal caspase Bcl-2 family of proteins BH3-only family of proteins mitochondrial proteins |
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