SO2的危害及其流行病学与毒理学研究

二氧化硫(SO2)是大气中最常见的污染物之一.SO2的大量排放使城市空气污染不断加重,对环境和人类健康造成了极大的危害.大量的流行病学研究表明SO2不仅可以引起呼吸系统疾病,而且对心血管系统,甚至生殖系统都会产生影响;毒理学研究也表明SO2对人和动物多种组织器官均有毒性作用,有些毒作用甚至比肺组织的改变还要严重,SO2是一种全身性毒物.而通过产生各种自由基引起器官组织发生氧化损伤作用可能是SO2毒作用的一种主要机制.

Damage Effects of SO2 and Its Epidemiology and Toxicology Research

Sulfur dioxide (SO2) is one of the most important air pollutants all over the world, which makes city environment deteriorated and has severely threatened human health. Many studies of epidemiology show that SO2 can not only cause respiratory tract diseases,but also affect cardiovascular system and genital system; Toxicology evidences also indicate that SO2 may cause toxicological damage to multiple organs of animals, and some of them are even severer than damages in lungs. Therefore, SO2 is a systemic toxin. Oxidative stress, which was caused by a lot of free radicals produced during the period of the sulfite and bisulfite oxidation, may be the main toxicological mechanism of SO2.