卤代苯对酵母菌的毒性研究

TOXICITY OF HALOGENATED-BENZENE TO SACCHAROMYCES CEREVISIAE

The toxicity of halogneated-benzene to Saccharomyces cereviszae was measured by theminimum sample concentration which produced clear inhibition zone on pre-seeded agarplate. The samples were dissolved in DMSO-Glycol(80: 20(W/W) )carrier solvent.TheresuIts were correlated with n-octanol/water partition coefficient and molecular connectivityindices.log(1/C_min)=0.773 logK_ow-0.834,R=0.985,S=0.815,N=14log(1/C_min)=0.2950°X^v+0.6721X^v-2.57,R=0.989,S=0.0743,N=14The results were also compared to the toxicity of halogenated-benzene to photobacteriumphosphoreum,fathead minnow and rat,which were also correlated with each other. Theregression of the toxicity to Saccharomyces cerevislae on the toxicity to fathead minnow andthe regression of toxicity to Saccharomyces cerevisiae on the toxicity to rat had almost thesame slope(0.993 and 0.973 respectively),while on the toxicity photobacterium phospho-reum 1.52,which means the toxic effect to eucaryotic Saccharomyces cerevisiae and to fat-head minnow and rat are at same level.