Prenatal exposure to organochlorine compounds and neuropsychological development up to two years of life |
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| Institution: | 1. International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), School of Water Conservancy and Civil Engineering, Northeast Agricultural University, Harbin, Heilongjiang 150030, PR China;2. IJRC-PTS, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, Heilongjiang 150090, PR China;3. IJRC-PTS-NA, Toronto M2N 6X9, Canada;1. Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain;2. CIBER de Epidemiología y Salud Pública (CIBERESP), Spain;3. Universitat Pompeu Fabra (UPF), Barcelona, Spain;4. University of Valencia, Valencia, Spain;5. Centre for Public Health Research (CSISP)-FISABIO, Valencia, Spain;6. Public Health Division of Gipuzkoa, Basque Government, Spain;7. Health Research Institute, Biodonostia, San Sebastián, Spain;8. Department of Social Medicine, Faculty of Medicine, University of Crete, Greece;9. Inserm, Rennes, France;10. University of Rennes I, Rennes, France;11. Department of Genes and Environment, Norwegian Institute of Public Health, Oslo, Norway;12. Centro de Investigación BioMédica, University of Granada, San Cecilio University Hospital, Granada, Spain;13. Environmental Risk and Health, Flemish Institute for Technological Research (VITO), Mol, Belgium;14. Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDÆA-CSIC), Barcelona, Spain;15. Department of Public Health Sciences, School of Medicine, University of CA, Davis, USA;p. Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Bochum, Germany;q. Department of Environmental Health, National Institute for Health and Welfare (THL), Kuopio, Finland;r. National School of Public Health, Athens, Greece;s. Slovak Medical University, Bratislava, Slovakia;t. IUF — Leibniz Research Institute for Environmental Medicine, Duesseldorf, Germany;u. Department of Biomedical Sciences, University of Antwerp (UA), Antwerp, Belgium;v. Department of Occupational Medicine and Public Health, Faroese Hospital System, Faroe Islands;w. Ib-salut, Area de Salut de Menorca, Menorca, Spain;x. Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark;y. Erasmus MC Sophia Children''s Hospital, University Medical Centre, Department of Pediatrics, Rotterdam, The Netherlands;z. Department of Occupational and Environmental Medicine, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark;1. The Key Laboratory of Food Safety Risk Assessment, Ministry of Health (CFSA) and China National Center for Food Safety Risk Assessment, Beijing, China;2. State Key Lab of Food Science and Technology, School of Food Science and Technology, Nanchang University, Nanchang, China;3. Department of Obstetrics and Gynecology, Beijing Fengtai Hospital, Beijing, China. |
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| Abstract: | Polychlorinated biphenyls (PCB), hexachlorobenzene (HCB), and dichlorodiphenyl dichloroethylene (pp′DDE) are persistent, bioaccumulative, and toxic environmental pollutants with potential neurotoxic effects. Despite a growing body of studies investigating the health effects associated with these compounds, their specific effects on early neuropsychological development remain unclear. We investigated such neuropsychological effects in a population-based birth cohort based in three regions in Spain (Sabadell, Gipuzkoa, and Valencia) derived from the INMA Environment and Childhood] Project. The main analyses in this report were based on 1391 mother–child pairs with complete information on maternal levels of organochlorine compounds and child neuropsychological assessment (Bayley Scales of Infant Development) at age 14 months. We found that prenatal PCB exposure, particularly to congeners 138 and 153, resulted in impairment of psychomotor development (coefficient = − 1.24, 95% confidence interval = − 2.41, − 0.07), but found no evidence for effects on cognitive development. Prenatal exposure to pp′DDE or HCB was not associated with early neuropsychological development. The negative effects of exposure to PCBs on early psychomotor development suggest that the potential neurotoxic effects of these compounds may be evident even at low doses. |
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