Air pollution exposure and telomere length in highly exposed subjects in Beijing,China: A repeated-measure study |
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| Institution: | 1. Unit of Teaching and Research in Occupational and Environmental Health, Department of Public Health, Faculty of Health Sciences, University of Abomey-Calavi, Benin;2. Centre National Hospitalier et Universitaire de Pneumo-Phtisiologie, Cotonou, Benin;3. Department of internal medicine, Egerton University, Kenya;4. Department of Internal Medicine, Douala General Hospital, Cameroon Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon;5. Department of Medicine, Obafemi Awolowo University, Ile Ife, Nigeria;6. Center for Health Research, Kaiser Permanente Northwest, Portland, USA;7. Dept. of Public Health, Occupational and Environmental Insurance Medicine, KU Leuven, Leuven, Belgium;8. National Heart & Lung Institute, Imperial College, London, UK;1. Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China;2. Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning 530021, China;3. Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning 530021, China;4. Department of Public Health, School of Medicine, Guangxi University of Science and Technology, Liuzhou 545006, Guangxi, China |
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| Abstract: | BackgroundAmbient particulate matter (PM) exposure has been associated with short- and long-term effects on cardiovascular disease (CVD). Telomere length (TL) is a biomarker of CVD risk that is modified by inflammation and oxidative stress, two key pathways for PM effects. Whether PM exposure modifies TL is largely unexplored.ObjectivesTo investigate effects of PM on blood TL in a highly-exposed population.MethodsWe measured blood TL in 120 blood samples from truck drivers and 120 blood samples from office workers in Beijing, China. We measured personal PM2.5 and Elemental Carbon (EC, a tracer of traffic particles) using light-weight monitors. Ambient PM10 was obtained from local monitoring stations. We used covariate-adjusted regression models to estimate percent changes in TL per an interquartile-range increase in exposure.ResultsCovariate-adjusted TL was higher in drivers (mean = 0.87, 95%CI: 0.74; 1.03) than in office workers (mean = 0.79, 95%CI: 0.67; 0.93; p = 0.001). In all participants combined, TL increased in association with personal PM2.5 (+ 5.2%, 95%CI: 1.5; 9.1; p = 0.007), personal EC (+ 4.9%, 95%CI: 1.2; 8.8; p = 0.01), and ambient PM10 (+ 7.7%, 95%CI: 3.7; 11.9; p < 0.001) on examination days. In contrast, average ambient PM10 over the 14 days before the examinations was significantly associated with shorter TL (? 9.9%, 95%CI: ? 17.6; ? 1.5; p = 0.02).ConclusionsShort-term exposure to ambient PM is associated with increased blood TL, consistent with TL roles during acute inflammatory responses. Longer exposures may shorten TL as expected after prolonged pro-oxidant exposures. The observed TL alterations may participate in the biological pathways of short- and long-term PM effects. |
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