Organophosphate pesticide exposure and perinatal outcomes in Shanghai,China |
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| Institution: | 3. Universidad Autónoma Metropolitana Unidad Iztapalapa, San Rafael Atlixco 186, Colonia Vicentina, Iztapalapa 09340, México;4. Unidad de Medicina Experimental, Facultad de Medicina, UNAM-Hospital General de México, Dr. Balmis 148, Colonia Doctores, Cuauhtémoc 06726, México;1. INSERM-IRSET n° 1085, Epidemiological Research on Environment, Reproduction and Development, University of Rennes 1, Rennes, France;2. Department of Epidemiology and Public Health, University Hospital, Rennes, France;3. Research Centre for Psychology, Cognition and Communication, University of Rennes 2, Rennes, France;4. LABOCEA Laboratory, Plouzané, France;5. Department of Pediatrics, University Hospital, Rennes, France;1. Paediatric Surgery Unit, Amiens University Hospital, F-80054 Amiens, France;2. PeriTox - UMI 01, UFR de Médecine, Jules Verne University of Picardy, F-80054 Amiens, France;3. Paediatric Intensive Care Unit, Amiens University Hospital, F-80054 Amiens, France;4. Department of Paediatrics, Amiens University Hospital, F-80054 Amiens, France;5. Neonatal Intensive Care Unit, Amiens University Hospital, F-80054 Amiens, France;1. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States;2. Rollins School of Public Health, Emory University, Atlanta, GA, United States;3. Department of Preventive Medicine, Mount Sinai School of Medicine, New York, NY, United States |
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| Abstract: | Although pesticide use is widespread in China, little is known about levels of exposure to organophosphate pesticides in the population and its potential adverse health effects. We investigated levels of organophosphate exposure in pregnant women and the association between organophosphate exposure and perinatal outcomes in Shanghai, China, by enrolling 187 healthy pregnant women between September 2006 and January 2007. Pesticide exposure was assessed by a questionnaire administered to the mothers in the hospital after delivery as well as by analyses of maternal urinary nonspecific metabolites of organophosphate pesticides (dimethyl and diethyl phosphates). Information on birth weight and length was collected from medical records. Geometric means of metabolites were 25.75 μg/L for dimethylphosphate (DMP); 11.99 μg/L for dimethylthiophosphate (DMTP); 9.03 μg/L for diethylphosphate (DEP); and 9.45 μg/L for diethyldithiophosphate (DETP). We found that a log unit increase in urinary DEP was associated with a decrease in gestational duration in girls by 1.79 weeks. ßadjusted = ? 1.79 weeks per log10 unit increase; 95% confidence interval (CI), ?2.82 to ? 0.76; p = 0.001]. These data suggest that high pesticide level might adversely affect duration of gestation although this association was not present among boys. No associations for any of the organophosphate exposure measures were present for birth weight and length, suggesting that organophosphate pesticides may have no effects on fetal growth. Given that maternal urine pesticide levels in Shanghai were much higher than those reported in developed countries, more studies on the effects of in utero organophosphate exposure on fetal growth and child neurodevelopment are warranted. |
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