Circulating levels of Persistent Organic Pollutants (POPs) among elderly men and women from Sweden: Results from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) |
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| Institution: | 1. MTM Research Centre, School of Science and Technology, Örebro University, SE-701 82 Örebro, Sweden;2. Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, SE-751 85 Uppsala, Sweden;3. Department of Medical Sciences, Acute and Internal Medicine, Uppsala University, SE-751 85 Uppsala, Sweden;1. Univ. Orléans, CNRS, ICOA, UMR-7311, F-45067 Orléans, France;2. Normandie Univ, France;3. UNICAEN, ABTE EA4651, F-14032 Caen, France;4. Centre François Baclesse, F-14076 Caen, France;1. Aarhus University, Faculty of Science and Technology, Department of Bioscience, Arctic Research Centre, Roskilde, Denmark;2. Technical University of Denmark, National Food Institute, Søborg, Denmark;3. Department of Biology, Norwegian University of Science and Technology, Trondheim, Norway;4. Wildlife and Landscape Science Directorate, Science and Technology Branch, Environment Canada, National Wildlife Research Centre, Carleton University, Ottawa, Canada;1. School of Public Health, Seoul National University, Seoul, 08826, Republic of Korea;2. CRI Global Institute of Toxicology, Croen Inc., Suwon, 16614, Republic of Korea;3. Korea Environment Institute, Sejong, 30147, Republic of Korea;4. School of Earth and Environmental Sciences & Research Institute of Oceanography, Seoul National University, Seoul, 08826, Republic of Korea;5. Department of Veterinary Biomedical Sciences & Toxicology Centre, University of Saskatchewan, Saskatoon, SK, Canada;6. Oil and POPs Research Group, Korea Institute of Ocean Science and Technology (KIOST), Geoje, 53201, Republic of Korea;1. Department of Orthopedic Surgery, Brigham and Women’s Hospital, Boston, MA, USA;2. Department of Plastic and Oral Surgery, Boston Children’s Hospital, Boston, MA, USA;3. Department of Oral and Maxillofacial Surgery, Harvard School of Dental Medicine, Boston, MA, USA;4. Department of Orthopedic Surgery, Harvard Medical School, Boston, MA, USA;1. Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo NEUROMED, Pozzilli (IS), Italy;2. Department of Medicine and Surgery, Research Center in Epidemiology and Preventive Medicine (EPIMED), University of Insubria, 21100 Varese, Italy |
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| Abstract: | Persistent Organic Pollutants (POPs) are a huge group of chemicals that have been linked to various adverse health effects in humans. Large epidemiological studies investigating gender differences in levels of POPs in the elderly are limited and the results from these are not always consistent. The present study was undertaken to examine the background levels of a broad range of POPs in human plasma samples among elderly men and women from Sweden and to assess the influence of gender. Levels of 23 POPs were determined in plasma samples collected during 2001–2004 from 1016 (50.2% women) 70 year-old participants from the population-based Prospective Study of the Vasculature in Uppsala Seniors (PIVUS). Measurements were performed using high resolution gas chromatography with high resolution mass spectrometry (HRGC-HRMS) and the POPs studied were 16 polychlorinated biphenyls (PCBs), five organochlorine (OC) pesticides, one dioxin, and one brominated flame retardant. The concentrations of the selected POPs were found similar, or comparable, to other studies of non-occupationally exposed populations from Sweden and Europe. Differences in levels of POPs between men and women were assessed by using Wilcoxon rank-sum (Mann–Whitney) test. Significant (p < 0.0001) gender differences in levels of specific POPs were observed and a number of POP concentrations were found to differ between men and women. More specifically, levels of HCB, OCDD, and PCB congeners #74, #105, and #118 were found to be higher in women, while the rest of the majority of POPs were higher in men. |
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