Distribution and bioconcentration potential of the environmental chemical pentachlorophenol (PCP) in different tissues of humans |
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| Affiliation: | 1. State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Jiangsu 201146, China;2. Soil Water Science Department, University of Florida, Gainesville, FL 32611, United States;3. Department of Environmental Engineering and Science, University of Florida, Gainesville, FL 32611, United States |
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| Abstract: | The bioconcentration factors (BCFs) of pentachlorophenol (PCP) in different tissues, organs and body fluids of humans were calculated by two methods: 1) from daily intake of PCP and its measured concentrations in different tissues and, 2) from measured half-life and measured PCP concentrations in the human body at steady state using a linear one compartment pharmacokinetic model. The BCFs (based on wet weight) in liver, brain, blood, spleen and adipose tissue of humans as calculated by method 1 were 5.7, 3.3, 1.4, 1.4, and 1.0, respectively. The figures obtained by method 2 were in good agreement to those obtained by method 1. |
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