Correlation between the bioconcentration potential of organic environmental chemicals in humans and their n-octanol/water partition coefficients |
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| Institution: | 1. IVL Swedish Environmental Research Institute, SE-100 31 Stockholm, Sweden;2. VITO NV Flemish Institute for Technological Research, Boeretang 200, 2400 Mol, Belgium;3. Toxicological Center, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitplein 1, B-2610 Wilrijk, Belgium;4. Department of Environmental Science and Analytical Chemistry (ACES), Stockholm University, SE-106 91 Stockholm, Sweden |
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| Abstract: | A quantitative relationship was found to exist between the lipophilicity (n-octanol/water partition coefficient) of pentachlorophenol, dieldrin, hexachlorobenzene, 2,3,7,8-tetrachlorodibenzo-p-dioxin, Σ DDT, polychlorinated biphenyls, α-, β-, γ- and δ -hexachlorocyclohexane and their bioconcentration factor (BCF) in human adipose tissue. The equations were used to predict the bioconcentration factors of some chlorinated aromatic chemicals. |
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