| DEHP、DBP内分泌干扰活性的实验研究 |
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| 引用本文： | 解玮,蒋颂辉,屈卫东,朱惠刚.DEHP、DBP内分泌干扰活性的实验研究[J].中国环境科学,2004,24(1):0-0. |
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| 作者姓名： | 解玮 蒋颂辉 屈卫东 朱惠刚 |
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| 作者单位： | 复旦大学公共卫生学院 上海200032 |
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| 基金项目： | 国家“863”项目(2002AA601130) |
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| 摘 要： | 利用MCF-7细胞增殖实验、细胞周期分析、细胞雌激素受体水平测定和断乳大鼠子宫增重实验探讨了邻苯二甲酸二乙基己酯(DEHP)和邻苯二甲酸二丁酯(DBP)内分泌干扰活性及其可能的作用机制.结果表明,DEHP和DBP可诱导MCF-7细胞增殖、细胞内雌激素受体水平增高,对细胞周期无明显影响,DEHP不引起断乳大鼠子宫增重.推断DEHP和DBP可能并不是通过模拟雌激素而是引起体内天然激素受体水平改变等其他机制影响机体内分泌系统.
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| 关 键 词： | 邻苯二甲酸二乙基己酯 邻苯二甲酸二丁酯 内分泌干扰活性 MCF-7人乳腺癌细胞 雌激素受体 |
| 文章编号： | 1000-6923(2004)01-0045-04 |
| 收稿时间： | 1900-01-01; |
| 修稿时间： | 2003年5月6日 |
Experimental studies on the endocrine disrupting activity of DEHP and DBP |
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| XIE Wei,JIANG Song-hui,QU Wei-dong,ZHU hui-gang.Experimental studies on the endocrine disrupting activity of DEHP and DBP[J].China Environmental Science,2004,24(1):0-0. |
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| Authors: | XIE Wei JIANG Song-hui QU Wei-dong ZHU hui-gang |
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| Abstract: | MCF-7 cell proliferation experiment, cell cycle analysis, cell estrogen receptors level determination and rat weight increase uterotropic experiment were used to explore endocrine disrupting activity and its possible action of Di (2-ethylhexyl) phthalate (DEHP) and Dibutyl phthalate (DBP). DEHP and DBP could induce MCF-7 cell proliferation and increase the level of estrogen receptors in the cell, did not influence markedly the cell cycle and induce the rat uterotropic. It was inferred that the influence of DEHP and DBP on endocrine system might not be obtained through mimic estrogen; but through inducement of other mechanism such as change of natural hormone level. |
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| Keywords: | di (2-ethylhexyl) phthalate dibutyl phthalate endocrine disrupting activity MCF-7 human breast cancer cell estrogen receptor |
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