Protective effect of Spirulina platensis against aluminium-induced nephrotoxicity and DNA damage in rats |
| |
| Authors: | Taghred M Saber Shimaa A Elgaml Haytham A Ali Ayman A Saleh |
| |
| Institution: | 1. Forensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypttaghred_saber@yahoo.com;3. Department of Clinical Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt;4. Department of Biochemistry, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt;5. Department of Animal Wealth Development, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt |
| |
| Abstract: | The protective effect of Spirulina platensis (SP) powder against aluminium-induced nephrotoxicity and DNA damage in rats was studied. Male rats receiving daily 40 mg/kg b.wt. aluminium chloride (AlCl3) orally had increased serum levels of urea and creatinine, up regulated kidney injury molecule-1 and tissue inhibitor of metalloproteinase-1 genes, down regulated catalase and glutathione peroxidase genes, and increased all parameters of kidney DNA damage using comet assay. Treatment with SP alleviated all AlCl3-induced effects of toxicity, especially when the animals were pre-treated. |
| |
| Keywords: | aluminium nephrotoxicity genotoxicity Spirulina platensis gene expression |
|
|
