Evaluation of antioxidant potentials of Morinda morindoides leaf extract |
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Authors: | Dorcas Ibukun Akinloye Taofik Olatunde Sunmonu Samuel Olatunbosun Omotainse Elisabeth Abidemi Balogun |
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Affiliation: | 1. Department of Biochemistry, Federal University of Agriculture, Abeokuta, Nigeriaakinloyedi@funaab.edu.ng;3. Department of Biological Sciences, Al-Hikmah University, Ilorin, Nigeria;4. Department of Veterinary Pathology, Federal University of Agriculture, Abeokuta, Nigeria;5. Department of Biochemistry, Faculty of Science, University of Ilorin, Ilorin, Nigeria |
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Abstract: | This study investigated antioxidant status of animals given aqueous extract of Morinda morindoides leaves using the levels of reduced glutathione, total-thiol, vitamin C, and vitamin E as well as malondialdehyde concentrations as indices, and its in vitro antioxidant capacity. Thirty rats divided into five groups were used. Group A served as control and were administered distilled water while groups B, C, D, and E were given 100, 200, 400, and 800 mg per kilogram body weight of water-extracted constituents of M. morindoides for 28 days. Total phenolic compounds amounted to 83.6 ± 5.9 mg g?1 gallic acid equivalent, while total flavonoid content was 9.5 ± 0.9 mg g?1 pyrocathecol equivalent. Malondialdehyde in plasma was significantly decreased in a dose-dependent manner, ranging from 21% in groups B and C to 84% in groups D and E. Vitamins C and E were significantly increased, in group E by 91% and 17% compared with control. Total thiols and glutathione in plasma were significantly increased, with group E having 2.5-fold and 4.2-fold higher values than control. |
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Keywords: | evaluation antioxidant Morinda morindoides leaf extract |
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