Noroviruses: State of the Art |
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Authors: | Robert L Atmar |
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Institution: | (1) Department of Medicine, Baylor College of Medicine, 1 Baylor Plaza, MS BCM 280, Houston, TX 77030, USA |
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Abstract: | Noroviruses are a common cause of both endemic and epidemic gastroenteritis. These highly infectious viruses usually cause
self-limited disease, but chronic infections occur in highly immunocompromised patients and unusual manifestations are also
being described in some populations. Histoblood-group antigen expression is now recognized as an important susceptibility
factor for many norovirus strains, but a correlate of acquired immunity to infection or illness has not yet been identified.
Currently, treatment and prevention strategies rely on non-specific measures. However, virus-like particles containing capsid
antigens are undergoing evaluation as a vaccine candidate for illness prevention. This article reviews the biologic properties,
epidemiology, clinical features, host susceptibility, diagnosis, and treatment and prevention of norovirus infection. |
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Keywords: | |
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