苏丹红Ⅰ、Ⅲ和Ⅳ对HepG-2细胞和SGC-7901细胞增殖的影响

以辽宁某地硼矿开采和加工厂的硼作业工人以及远离硼矿的背景地区的人群作为研究对象,分析了班后尿液硼浓度与日硼暴露剂量之间的关系.结果表明,班后尿硼浓度与日硼暴露剂量之间存在着显著的对数线性关系,考虑了不同人群类别的影响之后,回归方程的拟合度达到85.9%,由此确立了用班后尿硼浓度预测日硼暴露剂量的预测方程.用此预测方程对本研究2004年的受试者日硼暴露剂量进行预测,并与实测值进行了比较,结果表明平均相对偏差为13.4%,预测值与实测值之间没有显著性的差异.说明用班后尿硼浓度预测日硼暴露剂量是可行的.对2004年所有受试者的日硼暴露剂量预测结果分析表明,硼职业暴露组、社区对照组和背景对照组的日硼暴露剂量平均值分别为36.1、4.13和1.31mg/d.

Effect of Sudan I, III and IV on proliferation of HepG-2 and SGC-7901

Relationship between post-shift boron concentration and daily boron exposure was analyzed with the workers from boron mining and processing plants in Liaoning Province and population from sanitary background area far from boron industry as subjects.The results demonstrate that there was significant logarithm linearity correlativity between post-shift urine boron concentration and daily boron exposure,and the fittingness of the regression equation was up to 85.9% by considering of the effect of the different group of population,and the equation predicting daily boron exposure by post-shift urine boron concentration was determined.Daily boron exposures of the subjects in 2004 were predicted using this equation.Comparing of the daily boron exposure observed,the average of deviation between the boron exposures predicted and observed was 13.4%,and there was no significant difference between the exposure value predicted and observed.Therefore,It is feasible to predict daily boron exposure by boron concentration of post-shift urine.The analyzing of predicted daily boron exposure of all subjects in 2004 show that the daily boron exposure of peoples from occupational exposure group,community group and background control group were respectively 36.1,4.13 and 1.31mg/d.