| Chronic administration of triclosan leads to liver fibrosis through hepcidin-ferroportin axis-mediated iron overload |
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| 作者姓名： | Jing Liu Lecong Zhang Fang Xu Ping Zhang Yang Song |
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| 作者单位： | 1. College of Eco-Environmental Engineering, Guizhou Minzu University;2. The Institute of Karst Wetland Ecology, Guizhou Minzu University;3. State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences |
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| 基金项目： | supported by the National Natural Science Foundation of China (No. 22166012)； |
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| 摘 要： | Triclosan(TCS) has been manufactured as an antibacterial compound for half a century.Currently, it is widely used in various personal care products; however, its potential adverse effects raise a lot of attention. Here, we create a long-term oral administration mouse model and identify the corresponding hepatotoxicity of TCS. We discover that daily intragastric administration of 10 mg/kg TCS to mice for 12 weeks results in severe hepatic fibrosis. Further study displays that hepatic iron increas...
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