| Role of inflammatory lipid and fatty acid metabolic abnormalities induced by plastic additives exposure in childhood asthma |
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| 作者姓名： | Zhiyu Chen Fang Li Lei Fu Yu Xia Ying Luo Ang Guo Xiaona Zhu Huifang Zhong Qian Luo |
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| 作者单位： | 1. Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences;2. University of Chinese Academy of Sciences;3. Rheumatology &Immunology Department of Shenzhen Children's Hospital;4. Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, Institute of Environment and Health, Jianghan University |
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| 基金项目： | supported by the National Natural Science Foundation of China (Nos. 22076197, 21707149 and 82127801)；;Shenzhen Science and Technology Research Funding (Nos. JCYJ20210324115811031 and JCYJ20200109115405930)；;Guangdong Basic and Applied Basic Research Foundation (No. 2020B1515120080)； |
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| 摘 要： | Lipid metabolism play an essential role in occurrence and development of asthma, and it can be disturbed by phthalate esters(PAEs) and organophosphate fame retardants(OPFRs).As a chronic infammatory respiratory disease, the occurrence risk of childhood asthma is increased by PAEs and OPFRs exposure, but it remains not entirely clear how PAEs and OPFRs contribute the onset and progress of the disease. We have profiled the serum levels of PAEs and OPFRs congeners by liquid chromatography coupled w...
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