| Polystyrene nanoplastics induce glycolipid metabolism disorder via NF-κB and MAPK signaling pathway in mice |
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| 作者姓名： | Xingpei Fan Xiaoyan Li Jiaxin Li Yuxia Zhang Xiangjuan Wei Hailong Hu Boya Zhang Haining Du Meimei Zhao Ruijiao Zhu Daqian Yang Yuri Oh Ning Gu |
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| 作者单位： | 1. School of Life Science and Technology,Harbin Institute of Technology;2. State Key Laboratory of Urban Water Resource and Environment,Harbin Institute of Technology;3. Department of Medicine,Renal Electrolyte and Hypertension Division,Department of Genetics,Perelman School of Medicine,University of Pennsylvania;4. Faculty of Education,Wakayama University |
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| 基金项目： | the Natural Science Foundation of Heilongjiang Province (No. LH2021B012)；;the Fundamental Research Funds for the Central Universities (No. HIT.NSRIF202209)； |
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| 摘 要： | Nanoplastics-induced developmental and reproductive toxicity,neurotoxicity and immunotoxicity are a focus of widespread attention.However,the effects of nanoplastics (NPs) on glycolipid metabolism and the precise underlying mechanisms are unclear at present.Here,we showed that oral administration of polystyrene nanoparticles (PS-NPs) disrupts glycolipid metabolism,with reactive oxygen species (ROS) identified as a potential key signaling molecule.After PS-NPs treatment,excessive production of RO...
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